Eagle Pharmaceuticals March 2018

Forward Looking Statements This presentation contains forward-looking information within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, and other securities laws. Forward-looking statements are statements that are not historical facts. Words such as “will,” “underway,” “allow,” “expect(ed),” “pursuing,” “may,” “would,” “addressing,” “creating,” “intends,” “anticipate(s),” “plan,” “partner,” “could,” “enables,” “potential(ly),” and similar expressions are intended to identify forward-looking statements. These statements include, but are not limited to, statements regarding future events such as: the continued commercial performance of our marketed products, including but not limited to BENDEKA, which is marketed by our partner Teva, the ability of SymBio to obtain regulatory approval for its bendamustine products; whether SymBio will be successful at commercializing the licensed products; whether Eagle and SymBio will perform their respective obligations under the license agreement; inaccurate sales forecasts and estimates; forecasted sales of $90 million in 2018; forecasted sales of Bendeka in 2018; SymBio’s plans to secure regulatory approval of bendamustine HCl in a 500 mL ready to infuse and/or a 50 mL rapid infusion presentation; SymBio’s target to market the smaller volume product in Japan in 2020; the success of Eagle’s commercial relationship with SymBio and the companies’ ability to successfully work together; payments due to Eagle under the license with SymBio, including milestone and royalty payments; Argatroban, which is marketed by Chiesi USA and Sandoz pursuant to separate agreements and Ryanodex, which we market ourselves, as well as our ability to replicate our marketing successes for our other product candidates such as Ryanodex for EHS or other additional indications, our pemetrexed product candidate, our long infusion bendamustine candidate, or our fulvestrant product candidate, either through joint or direct marketing efforts; the potential lack of a need for human safety and efficacy data for the submission of an NDA for Ryanodex and the adequacy of the regulatory pathway to complete an NDA submission; the Company’s share repurchase authorization and timing and ability to continue to repurchase shares of the Company’s common stock under a share repurchase program; the business path forward for the Company between now and beyond 2026; the label expansions of Ryanodex for EHS patients and for the treatment of ecstasy and methamphetamine intoxication and for the treatment of neurological impact and nerve agent exposure; the strength of the Company’s cash position and the ability to optimize the deployment of capital and take advantage of market opportunities; the potential of the Company’s pipeline to drive value between now and beyond 2026; the contribution of the Ryanodex portfolio to the Company’s growth; the timing of Ryanodex for EHS obtaining FDA approval, if ever, and, entering the market; and the advancement of any of the Company’s other product candidates including but not limited to fulvestrant and pemetrexed, through the development process including FDA approval and the ability of any such products to have commercial success and to access significant new markets; and our ability to use the acquisition of Arsia Therapeutics (now Eagle Biologics) to enter into the biologics market and to effectively carry out our strategy in this new market. All of such statements are subject to certain risks and uncertainties, many of which are difficult to predict and generally beyond Eagle’s control, that could cause actual results to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. Such risks include, but are not limited to: whether our animal studies will support the safety and efficacy of Ryanodex for the treatment of EHS, ecstasy and methamphetamine intoxication, and neurological impact of nerve agent exposure; whether the FDA will ultimately approve Ryanodex for these indications; whether the FDA will approve our application for pemetrexed, and, if filed, fulvestrant; fluctuations in the trading volume and market price of shares of the Company's common stock, general business and market conditions and management's determination of alternative needs and uses of the Company's cash resources which may affect the Company's share repurchase program; the success of our commercial relationship with Teva and our other marketing partners and the parties’ ability to work effectively together; whether Eagle and Teva and our other marketing partners will successfully perform their respective obligations under their agreements with us; difficulties or delays in manufacturing; the availability and pricing of third party sourced products and materials; the outcome of litigation involving any of our products or product candidates or that may have an impact on any of our products or product candidates, successful compliance with FDA and other governmental regulations applicable to product approvals, manufacturing facilities, products and/or businesses; general economic conditions; the strength and enforceability of our intellectual property rights or the rights of third parties; competition from other pharmaceutical and biotechnology companies; the timing of product launches; the successful marketing of our products; the risks inherent in the early stages of drug development and in conducting clinical trials; and other factors that are discussed in Eagle’s Annual Report on Form 10-K for the year ended December 31, 2017, its Quarterly Reports on Form 10-Q for each of the quarters ended March 31, 2017, June 30, 2017 and September 30, 2017 and its other filings with the U.S. Securities and Exchange Commission. Readers are cautioned not to place undue reliance on these forward-looking statements that speak only as of the date hereof, and we do not undertake any obligation to revise and disseminate forward-looking statements to reflect events or circumstances after the date hereof, or to reflect the occurrence of or non-occurrence of any events. 2

Eagle 2018 At A Glance 3 Driving near-term, sustainable value Pivotal trial commenced Q4 2017 Fulvestrant Positive regulatory feedback Innovative formulation offers opportunity similar to Bendeka Promoted by Eagle salesforce; pursuing add’l indications Ryanodex Agreed to a path forward on EHS with FDA (Feb 2018) Phase II clinical trial for MDMA/meth intoxication underway Potential next indication: treatment of neurological impact of exposure to nerve agents Two compounds in development Co-developed Assets Combined branded sales of ~$500 million Granted tentative approval for PEMFEXYTM Pemetrexed Began patent litigation in 2017 97% market share Bendamustine Orphan Drug Designation / in litigation for ODE Retained rights to launch big bag Licensed to SymBio in Japan in 2017 FDA approval for 2nd manufacturing site Entry into fastest growing pharma sector Eagle Biologics ‘Biobetter’ product potential Unique J-Code effective January 1, 2017 13 Orange Book Listed patents for Bendeka Sued four ANDA filers for patent infringement in 2017

2018: Poised for Growth 4 Multiple potential regulatory filings in 2018 Ryanodex EHS MDMA and Meth Intoxication Nerve agent Intramuscular Co-developed Assets Filed ANDA Q1 2018 Anticipate 2nd filing second half of 2018 Fulvestrant Complete study enrollment in first half of 2018 File Q4 2018 pending study results Bendeka OUS markets ROW

Fulvestrant Opportunity INDICATIONS for FASLODEX® Currently marketed by AstraZeneca Administered monthly in a doctor’s office as 2 separate intramuscular injections, one in each buttock FDA has recently required revising the FASLODEX label 5 Faslodex ® is a registered trademark of AstraZeneca. Label expanded in the U.S. to first line breast cancer in August 2017 Monotherapy FASLODEX is indicated for the treatment of hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer in postmenopausal women not previously treated with endocrine therapy, or HR-positive advanced breast cancer in postmenopausal women with disease progression following endocrine therapy Combination Therapy FASLODEX in combination with palbociclib is indicated for the treatment of HR-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer in women with disease progression after endocrine therapy.

The Problem 2 deep intramuscular injections of high viscosity product per dose of treatment (5 mL each) Administered over 1-2 minutes into each buttock Painful procedure FASLODEX injection reactions have been associated with peripheral nerve adverse reactions, including risk of damaging the sciatic nerve 6

Eagle’s Solution Innovative formulation administered in far less time (seconds) vs. 1-2 minutes per injection Eagle formulation may allow warning on insert to be eliminated Eagle formulation does not contain castor oil Eagle’s lower viscosity formulation allows for administration with smaller 23-gauge needle, 25% thinner than the current needle used to administer FASLODEX 1X Low viscosity 5 mL dose 2X High viscosity 5 mL doses vs. 7

Fulvestrant Clinical Protocol Completed randomization of 600 subjects ahead of schedule during the first quarter of 2018 A single PK and safety study in healthy female volunteers may be sufficient for filing Commenced dosing Q4 2017 with last patient being dosed around end of April 2018 Aiming to file an NDA by the early fourth quarter of 2018 Could qualify for its own unique J-code FDA has agreed to consider not including Injection Site Reaction (Warning & Precautions) language in Eagle’s label, provided that our clinical data demonstrates a significant safety improvement 8 Positive Regulatory Feedback from FDA

FASLODEX Market Opportunity $400mm+ O.U.S. Source: AstraZeneca Financial Summary Full Year and Q4 2017 Results Results) https://www.astrazeneca.com/content/dam/az/PDF/2017/Full-Year/Full-Year%202017%20Results%20announcement%20.pdf 9 2017 total sales of the branded form of fulvestrant, FASLODEX, were up 13% to $941 million worldwide 12% growth in US sales to $492 mm 12% growth in EU sales to $256 mm 15% growth in Established ROW sales to $78 mm 20% growth in Emerging Markets sales to $115 mm

RYANODEX®: Multiple Label Expansion Opportunities Creating additional value by addressing life-threatening, unmet needs Eight patents issued to date expiring from 2022 to 2025 Breakthrough formulation of dantrolene sodium Approved in July 2014; launched in August 2014 Agreed to path forward with FDA (Feb 2018) Potential to be the first drug to market for EHS Orphan Drug Designation Preclinical studies by NIDA/NIH completed Phase II clinical trial for MDMA & meth intoxication ongoing Broadened endpoint to include severe organ dysfunction and damage 125K U.S. ED visits in 2011 due to MDMA & meth intoxication New patent issued Marketed Potential Label Expansion Malignant Hyperthermia Exertional Heat Stroke MDMA & Methamphetamine Intoxication 10 Nerve Agent Treatment of neurological impact of nerve agent exposure as potential next indication Positive results of an initial study to evaluate the neuroprotective effects of RYANODEX in an established rodent model Plan to meet with FDA to discuss next steps Progress being made to an IM version of RYANODEX

Based on our recent meeting with the FDA, we have agreed on a path forward for an additional clinical trial for RYANODEX for EHS Originally received a CRL from the FDA on July 26, 2017 Will conduct additional clinical trial in August 2018 during the Hajj pilgrimage Similar to study conducted during the Hajj in 2015 Believe strongly in RYANODEX given that there is no pharmacological option available for patients in need for this life-threatening condition Label expansion for an already approved drug No safety or CMC issues Priority Review and Fast Track designation RYANODEX® for Exertional Heat Stroke 11

References: 1. Center for Behavioral Health Statistics and Quality, SAMHSA, Drug Abuse Warning Network, National Estimates of Drug-Related Emergency Department Visits, 2011. 2. E Musselman M, Saely S. Diagnosis and treatment of drug-induced hyperthermia. Am J Health-Syst Pharm. 2013 Vol 70. Over 125,000 ED visits related to MDMA (ecstasy) and methamphetamine use in the US alone (2011)1 Associated with body and brain hyperthermia, high incidence of severe cardiovascular and neurologic complications, and lifetime neurologic sequelae2 Can be fatal or lead to permanent damage if not treated promptly2 FDA suggested and we are broadening the indication to evaluate ‘organ damage and/or severe dysfunction’ in patients with MDMA and Methamphetamine intoxication Phase II clinical trial for MDMA & Methamphetamine intoxication underway enrollment slower than expected next wave of recruiting expected to begin at the end of March 2018 MDMA (Ecstasy) and Methamphetamine Intoxication 12

Pemetrexed Opportunity At this time, Lilly’s Alimta patent litigations prevent current ANDA filers from launching until May 24, 2022 FDA granted tentative approval of Eagle’s Pemetrexed RTD PEMFEXY™ Oct. 27, 2017 Lilly sued Eagle on August 14, 2017. Trial scheduled to begin on Sept. 9, 2019. There are four 505(b)(2) filers (DRL, Hospira, Actavis/Teva, Apotex) with a similar approach to Eagle’s (ours appears to be a differentiated product) DRL and Hospira both filed Motions for Summary Judgment of Noninfringement in late July 2017 DRL’s summary judgment motion was denied Hospira’s summary judgment briefing scheduled to be completed in Q4 2018 DRL went to trial in February 2018. We anticipate a decision by Q4 2018. Hospira trial scheduled to begin Dec. 3, 2018 Apotex was sued in August 2017. Trial is presumptively scheduled for July 2019 Eagle continues evaluating all litigations and outcomes Multi-billion market opportunity (LTM Sales: $1.03B U.S., $1.03B Ex-U.S., $2.06B WW)1 13 1 Alimta® (pemetrexed) (Eli Lilly & Co.). Source: Eli Lily & Company Quarterly Results; Statements of Consolidated Income – As Reported, Q4 2017; https://investor.lilly.com/results.cfm

Bendeka: Long Life Cycle 14 1/1/15-12/31/17: $126 mm in aggregate milestones earned 1/1/16-12/31/17: $235 mm in royalties earned Significant royalties and milestones earned 2016 - 2019 Unique J-code 8 newly listed patents through 2033 97% market share Royalty of 25% of US net sales (increased from 20% in Q4 2016) $25 mm milestone earned from Teva in 2017 US and expansion to OUS markets (20% royalty) $12.5 mm upfront payment for licensing agreement with SymBio in Japan FDA approval for 2nd manufacturing site 2020 – 2025 6 years of royalty of 25% net sales Assuming large market share held post generic Treanda® entry Improved product profile and J-code

Thirteen Orange Book Patents Running from 2026-2033 15 U.S. Patent No. Patent Expiration 8,609,707 1/28/2031 8,791,270*PED (owned by Teva Pharmaceutical Industries Ltd.) 7/12/2026 9,000,021 3/15/2033 9,034,908 3/15/2033 9,144,568 3/15/2033 9,265,831 1/28/2031 9,572,796 1/28/2031 9,572,797 1/28/2031 9,572,887 3/15/2033 9,579,384 3/15/2033 9,579,397 3/15/2033 9,579,398 3/15/2033 9,579,399 3/15/2033 Protecting the longevity of the bendamustine franchise Eagle/Teva asserting all patents challenged by ANDA filers

Licensed Japanese Rights for Bendamustine Hydrochloride Products to SymBio Pharmaceuticals Limited in Q4 2017 Develop, market and sell Eagle’s bendamustine HCI ready-to-dilute (RTD) and rapid infusion injection (RI) products $12.5 mm upfront payment plus future potential milestones and royalty payments SymBio is responsible for securing regulatory approval of the RTD and RI injection in Japan; targeting product approval in 2020 SymBio markets TREAKISYM® in Japan, a lyophilized powder formulation of bendamustine HCl for chronic lymphocytic leukemia (CLL); relapsed or refractory low-grade Hodgkin’s lymphoma (NHL); mantle cell lymphoma (MCL); and as a first line treatment of low-grade NHL and MCL 12-month sales ended June 30, 2017 for TREAKISYM in Japan were $52 million SymBio has estimated that sales of TREAKISYM will grow to $90 million in 2018 SymBio is conducting a Ph 3 clinical trial for relapsed/refractory diffuse large B-cell lymphoma SymBio Licensing Agreement for Bendamustine HCI 16 Begins process to maximize value of Eagle’s product portfolio worldwide

Eagle Biologics Market Opportunity Acquired Arsia Therapeutics in 2016 Enhances Eagle’s formulation capabilities and expands product development opportunities Extends Eagle’s strategy: plan to partner with key Biosimilar or Bioinnovator companies to alter their existing pipeline into “Biobetters” $45 million investment The global biologics market could exceed $390 billion in value over the next five years1 Growing at nearly 2X the rate of pharma1 By the end of 2020, biologics could account for 28% of the global pharmaceuticals market1 The global biosimilar market may reach $20 - $26 billion by 20202 17 References: 1. PRA Health Sciences Whitepaper. The Value of Biobetters. December 2015. 2. IMS Medicines Use and Spending in the U.S. – A Review of 2015 and Outlook to 2020. April 2015.

2018 Tax Reform Impact Eagle, as a U.S.-based tax payer, is expecting to benefit directly from the reduction in the U.S. Corporate tax rate from 35% to 21% beginning in 2018 Estimated combined effective tax rate of 24% As Eagle expands its portfolio globally, we may benefit further from even lower corporate rates in certain foreign jurisdictions The shift to territorial system obviates the need for U.S. companies to invert 18

Financial Highlights 2017 EBITDA: $96 mm LTM cash flow from operating activities, excluding A/R build: $71 mm Cash: $114.7 mm A/R: $53.8 mm Share Repurchase Plan $87.8 mm repurchased (1.4 mm shares at $64.32) since August 2016 $100 mm additional authorization approved by the Board August 2017 14.9 mm basic shares outstanding $150 mm credit facility August 2017 $100 mm term loan ($48.8 mm outstanding at 12/31/17) $50 mm revolver 19 As of 12/31/17

Poised for Continued Growth Beyond 2020 Ongoing Reinvestment of Cash Including Additional Share Repurchase Enhanced Management Team 20 Potential for multiple in-market products over the long-term 2017 - 2019 2020 - 2025 2025+ Multiple in-market products Use of Capital R&D success Bendeka US & WW Big bag Ryanodex for MH, EHS, MDMA & Methamphetamine Intoxication and Nerve Agent Co-developed Assets Argatroban Docetaxel Fulvestrant Pemetrexed Biobetters Bendeka US & WW Big bag Ryanodex for MH, EHS, MDMA & Methamphetamine Intoxication and Nerve Agent Co-developed Asset Argatroban Docetaxel Fulvestrant

Thank You March 2018 21