<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:ae90bf6a-e051-46fc-ba78-a2d5dff2c984,g:46067fb7-7518-4702-8e16-cf627b8bfa2e-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.eagleus.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="egrx-20211231.xsd#ConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.eagleus.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_692cd118-c25b-4800-9e3d-10c131bd4fe4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_04e330df-0c83-4730-8332-3525d3c77e2a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_692cd118-c25b-4800-9e3d-10c131bd4fe4" xlink:to="loc_us-gaap_Liabilities_04e330df-0c83-4730-8332-3525d3c77e2a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_f1648d02-d844-4737-a6e4-d3119bcb38a3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_692cd118-c25b-4800-9e3d-10c131bd4fe4" xlink:to="loc_us-gaap_StockholdersEquity_f1648d02-d844-4737-a6e4-d3119bcb38a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_88635f90-1034-4a97-8bd5-d62a89f2cf47" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_692cd118-c25b-4800-9e3d-10c131bd4fe4" xlink:to="loc_us-gaap_CommitmentsAndContingencies_88635f90-1034-4a97-8bd5-d62a89f2cf47" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_8e53f280-b3ff-41c5-9fdd-039224ad7c1e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_2a8eb2eb-6646-45fb-8768-bd7ea5309568" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_8e53f280-b3ff-41c5-9fdd-039224ad7c1e" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_2a8eb2eb-6646-45fb-8768-bd7ea5309568" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_3b2133d1-8233-4f21-be11-5a231b22e792" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_8e53f280-b3ff-41c5-9fdd-039224ad7c1e" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_3b2133d1-8233-4f21-be11-5a231b22e792" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_89975a9a-94b3-463a-9961-a52a3190ee7b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_8e53f280-b3ff-41c5-9fdd-039224ad7c1e" xlink:to="loc_us-gaap_InventoryNet_89975a9a-94b3-463a-9961-a52a3190ee7b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_52a030fd-0b1c-4348-b0ce-093cc839db5a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_8e53f280-b3ff-41c5-9fdd-039224ad7c1e" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_52a030fd-0b1c-4348-b0ce-093cc839db5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_973a9b79-575c-4c1f-9be6-57194701d1aa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_f5d9d1b7-5258-49d0-95aa-4a8983bd71af" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_973a9b79-575c-4c1f-9be6-57194701d1aa" xlink:to="loc_us-gaap_PreferredStockValue_f5d9d1b7-5258-49d0-95aa-4a8983bd71af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_48344e39-af92-4bb1-b5fb-dbb275ef92fb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_973a9b79-575c-4c1f-9be6-57194701d1aa" xlink:to="loc_us-gaap_CommonStockValue_48344e39-af92-4bb1-b5fb-dbb275ef92fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_67c1b30b-af35-4690-b792-164e375ab853" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_973a9b79-575c-4c1f-9be6-57194701d1aa" xlink:to="loc_us-gaap_AdditionalPaidInCapital_67c1b30b-af35-4690-b792-164e375ab853" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_7cb2300b-f5ef-451e-b1ee-1f0423af1bed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_973a9b79-575c-4c1f-9be6-57194701d1aa" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_7cb2300b-f5ef-451e-b1ee-1f0423af1bed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_c45b03fc-ffdf-470f-926b-01c0e8673d2c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockValue"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_973a9b79-575c-4c1f-9be6-57194701d1aa" xlink:to="loc_us-gaap_TreasuryStockValue_c45b03fc-ffdf-470f-926b-01c0e8673d2c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_aa51eb0e-117b-4c55-8d64-9f6da1f611ad" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_973a9b79-575c-4c1f-9be6-57194701d1aa" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_aa51eb0e-117b-4c55-8d64-9f6da1f611ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_9d236ad0-64e3-4aef-be74-1248579b44c4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_09d0652f-10e6-4891-b105-483c52158db1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_9d236ad0-64e3-4aef-be74-1248579b44c4" xlink:to="loc_us-gaap_AssetsCurrent_09d0652f-10e6-4891-b105-483c52158db1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_72ee0b0e-e65f-4fba-a4e0-b619351298ee" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_9d236ad0-64e3-4aef-be74-1248579b44c4" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_72ee0b0e-e65f-4fba-a4e0-b619351298ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_47705831-5668-4959-9278-06cc7e4bd69a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_9d236ad0-64e3-4aef-be74-1248579b44c4" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_47705831-5668-4959-9278-06cc7e4bd69a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_5801d51a-11e4-4318-85c7-52a3dc712553" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_9d236ad0-64e3-4aef-be74-1248579b44c4" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_5801d51a-11e4-4318-85c7-52a3dc712553" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_840f91bf-e01b-449e-87ff-8eb2a0f5da50" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_9d236ad0-64e3-4aef-be74-1248579b44c4" xlink:to="loc_us-gaap_Goodwill_840f91bf-e01b-449e-87ff-8eb2a0f5da50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_6304464a-e126-453a-b2dd-7163f6d246ad" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_9d236ad0-64e3-4aef-be74-1248579b44c4" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_6304464a-e126-453a-b2dd-7163f6d246ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_1cfe2076-d2c6-4f8e-b809-4e5dc5924224" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_7189cf60-146d-41ea-8096-b9972c8930d5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_1cfe2076-d2c6-4f8e-b809-4e5dc5924224" xlink:to="loc_us-gaap_LiabilitiesCurrent_7189cf60-146d-41ea-8096-b9972c8930d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_06282a63-b259-4db7-a0b6-10c01aaf59f3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_1cfe2076-d2c6-4f8e-b809-4e5dc5924224" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_06282a63-b259-4db7-a0b6-10c01aaf59f3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_f00a2155-62c6-4709-b88b-2b0aac57091f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_1cfe2076-d2c6-4f8e-b809-4e5dc5924224" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_f00a2155-62c6-4709-b88b-2b0aac57091f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_4a31794e-5ba1-4244-8931-27a5677995b2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_b8adc9cf-26a2-46ed-8e51-9da6f2cb4a30" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_4a31794e-5ba1-4244-8931-27a5677995b2" xlink:to="loc_us-gaap_AccountsPayableCurrent_b8adc9cf-26a2-46ed-8e51-9da6f2cb4a30" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_257c9f19-6351-45d7-8109-d70cb98b3dfa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_4a31794e-5ba1-4244-8931-27a5677995b2" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_257c9f19-6351-45d7-8109-d70cb98b3dfa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_d8447e7e-d7c8-420c-8207-fd81a4ccdb3f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_4a31794e-5ba1-4244-8931-27a5677995b2" xlink:to="loc_us-gaap_LongTermDebtCurrent_d8447e7e-d7c8-420c-8207-fd81a4ccdb3f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eagleus.com/role/ConsolidatedStatementsofIncome" xlink:type="simple" xlink:href="egrx-20211231.xsd#ConsolidatedStatementsofIncome"/>
  <link:calculationLink xlink:role="http://www.eagleus.com/role/ConsolidatedStatementsofIncome" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_99f63d32-faf3-4a92-950e-b679b4950983" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_2d0df11e-f11b-49c0-accd-f7070f8d5afb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_99f63d32-faf3-4a92-950e-b679b4950983" xlink:to="loc_us-gaap_InvestmentIncomeInterest_2d0df11e-f11b-49c0-accd-f7070f8d5afb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_87713368-e06c-4a13-ac51-9907aa67a62d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_99f63d32-faf3-4a92-950e-b679b4950983" xlink:to="loc_us-gaap_InterestExpense_87713368-e06c-4a13-ac51-9907aa67a62d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_903a9497-2489-4921-b87d-480819a09550" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_99f63d32-faf3-4a92-950e-b679b4950983" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_903a9497-2489-4921-b87d-480819a09550" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_bf4e2855-aa3f-4f50-8eaf-8a5112f4e77c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_c20120c7-185e-47d5-aa5b-6589b3c209c6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_bf4e2855-aa3f-4f50-8eaf-8a5112f4e77c" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_c20120c7-185e-47d5-aa5b-6589b3c209c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_0b49e4d6-aee4-4b4b-8354-c974f128e873" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_bf4e2855-aa3f-4f50-8eaf-8a5112f4e77c" xlink:to="loc_us-gaap_OperatingIncomeLoss_0b49e4d6-aee4-4b4b-8354-c974f128e873" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_584cd4f8-5935-4642-8c37-b830049a8203" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostsAndExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_ae385139-a810-4c39-975d-4892d3f80051" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_584cd4f8-5935-4642-8c37-b830049a8203" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_ae385139-a810-4c39-975d-4892d3f80051" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RoyaltyExpense_ee6d6296-4ad8-46a8-b2fd-a28adb756ce8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RoyaltyExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_584cd4f8-5935-4642-8c37-b830049a8203" xlink:to="loc_us-gaap_RoyaltyExpense_ee6d6296-4ad8-46a8-b2fd-a28adb756ce8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_c844d905-42a5-4e45-89e1-97aa3452198e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_584cd4f8-5935-4642-8c37-b830049a8203" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_c844d905-42a5-4e45-89e1-97aa3452198e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_3e41073e-8dfd-4855-b867-7105b9586d65" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_584cd4f8-5935-4642-8c37-b830049a8203" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_3e41073e-8dfd-4855-b867-7105b9586d65" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_4b7d24fe-6f91-4a66-af4b-0acab7e91820" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_b2cc019f-4ab0-47b7-8a5a-74f79cfb3a1f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_4b7d24fe-6f91-4a66-af4b-0acab7e91820" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_b2cc019f-4ab0-47b7-8a5a-74f79cfb3a1f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_7358682d-4305-4846-b7ca-22e4ac0a7b1c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostsAndExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_4b7d24fe-6f91-4a66-af4b-0acab7e91820" xlink:to="loc_us-gaap_CostsAndExpenses_7358682d-4305-4846-b7ca-22e4ac0a7b1c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_a38e6899-a100-49eb-a90f-fb5e0c5eda28" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_2e8cc9fd-4553-4a07-93cd-57ded07274c7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_a38e6899-a100-49eb-a90f-fb5e0c5eda28" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_2e8cc9fd-4553-4a07-93cd-57ded07274c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_3ffcdad2-f47c-4ce8-8cfd-f15f407e1ed7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_a38e6899-a100-49eb-a90f-fb5e0c5eda28" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_3ffcdad2-f47c-4ce8-8cfd-f15f407e1ed7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eagleus.com/role/ConsolidatedStatementsofComprehensiveLossIncome" xlink:type="simple" xlink:href="egrx-20211231.xsd#ConsolidatedStatementsofComprehensiveLossIncome"/>
  <link:calculationLink xlink:role="http://www.eagleus.com/role/ConsolidatedStatementsofComprehensiveLossIncome" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_2ba046a4-78f2-47dd-9428-a7db58ce6daf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_3ac9d928-58b5-4f2b-9f4a-77d1c155150d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_2ba046a4-78f2-47dd-9428-a7db58ce6daf" xlink:to="loc_us-gaap_NetIncomeLoss_3ac9d928-58b5-4f2b-9f4a-77d1c155150d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_b6a63b5c-2dd5-4e4a-b2bc-ab73d1294988" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_2ba046a4-78f2-47dd-9428-a7db58ce6daf" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_b6a63b5c-2dd5-4e4a-b2bc-ab73d1294988" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_760cd6f5-226c-4ed2-a018-082baf0db4fd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_e713c4d8-92e8-4726-b6b4-bd7a5bb768d7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_760cd6f5-226c-4ed2-a018-082baf0db4fd" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_e713c4d8-92e8-4726-b6b4-bd7a5bb768d7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eagleus.com/role/ConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="egrx-20211231.xsd#ConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.eagleus.com/role/ConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4c71f440-8821-48ec-8e6e-b56f3e40594f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_d5e9da70-5c0f-43fe-96ad-2eed00b145de" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4c71f440-8821-48ec-8e6e-b56f3e40594f" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_d5e9da70-5c0f-43fe-96ad-2eed00b145de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfDebt_453eef76-c1e9-4afa-8dcf-a9405b4d4874" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceOfDebt"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4c71f440-8821-48ec-8e6e-b56f3e40594f" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfDebt_453eef76-c1e9-4afa-8dcf-a9405b4d4874" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_51744713-de64-4055-be25-0e8614a4bbf3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4c71f440-8821-48ec-8e6e-b56f3e40594f" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_51744713-de64-4055-be25-0e8614a4bbf3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_138a5c07-80b2-49af-a241-a38ecb8e5af1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4c71f440-8821-48ec-8e6e-b56f3e40594f" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_138a5c07-80b2-49af-a241-a38ecb8e5af1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_5620c526-60cd-4fd3-8ab0-38e4056d4974" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4c71f440-8821-48ec-8e6e-b56f3e40594f" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_5620c526-60cd-4fd3-8ab0-38e4056d4974" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLinesOfCredit_98a41a76-62a1-46a7-b0fc-78c8386b58bf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepaymentsOfLinesOfCredit"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4c71f440-8821-48ec-8e6e-b56f3e40594f" xlink:to="loc_us-gaap_RepaymentsOfLinesOfCredit_98a41a76-62a1-46a7-b0fc-78c8386b58bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_100cea70-79be-409a-8268-2df08baf95e3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4c71f440-8821-48ec-8e6e-b56f3e40594f" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_100cea70-79be-409a-8268-2df08baf95e3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_44a3a8e7-c481-476b-93e0-0917230612a1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_e228d61f-73dc-4b6b-8eca-96a283249c18" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_44a3a8e7-c481-476b-93e0-0917230612a1" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_e228d61f-73dc-4b6b-8eca-96a283249c18" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireIntangibleAssets_052efe0c-ae2e-488d-92a1-785b075155ec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireIntangibleAssets"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_44a3a8e7-c481-476b-93e0-0917230612a1" xlink:to="loc_us-gaap_PaymentsToAcquireIntangibleAssets_052efe0c-ae2e-488d-92a1-785b075155ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireEquitySecuritiesFvNi_0dcb8595-4203-43da-9c62-90a88db8f426" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireEquitySecuritiesFvNi"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_44a3a8e7-c481-476b-93e0-0917230612a1" xlink:to="loc_us-gaap_PaymentsToAcquireEquitySecuritiesFvNi_0dcb8595-4203-43da-9c62-90a88db8f426" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a3140820-86f4-4014-802a-e0e945ac17a0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_4b16c031-4631-491b-895a-961a875a5ced" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a3140820-86f4-4014-802a-e0e945ac17a0" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_4b16c031-4631-491b-895a-961a875a5ced" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_bfdfddb0-b54c-4bd2-8a4d-263c8d9aa901" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a3140820-86f4-4014-802a-e0e945ac17a0" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_bfdfddb0-b54c-4bd2-8a4d-263c8d9aa901" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_egrx_IncreaseDecreaseinPrepaidExpenseandOtherCurrentAssetsTotal_344e6513-46b0-4f2e-b09a-78707adbd956" xlink:href="egrx-20211231.xsd#egrx_IncreaseDecreaseinPrepaidExpenseandOtherCurrentAssetsTotal"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a3140820-86f4-4014-802a-e0e945ac17a0" xlink:to="loc_egrx_IncreaseDecreaseinPrepaidExpenseandOtherCurrentAssetsTotal_344e6513-46b0-4f2e-b09a-78707adbd956" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities_69f9ee34-cba6-4ac9-9bdb-c1d2aff2359c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a3140820-86f4-4014-802a-e0e945ac17a0" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities_69f9ee34-cba6-4ac9-9bdb-c1d2aff2359c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_57fc000c-724d-406f-91d2-8a55e7e1dd9d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a3140820-86f4-4014-802a-e0e945ac17a0" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_57fc000c-724d-406f-91d2-8a55e7e1dd9d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_35fd5af2-91a8-43d8-a8e6-e2365d09fa9c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxesAndTaxCredits"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a3140820-86f4-4014-802a-e0e945ac17a0" xlink:to="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_35fd5af2-91a8-43d8-a8e6-e2365d09fa9c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_606dafb6-840e-49cc-852f-52e082278d16" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a3140820-86f4-4014-802a-e0e945ac17a0" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_606dafb6-840e-49cc-852f-52e082278d16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_10e3e061-00d8-41cf-af58-9f6f391c507c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a3140820-86f4-4014-802a-e0e945ac17a0" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_10e3e061-00d8-41cf-af58-9f6f391c507c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_egrx_AccretionIncome_003cd2b8-f255-45bc-82fb-bf5b4962e9f9" xlink:href="egrx-20211231.xsd#egrx_AccretionIncome"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a3140820-86f4-4014-802a-e0e945ac17a0" xlink:to="loc_egrx_AccretionIncome_003cd2b8-f255-45bc-82fb-bf5b4962e9f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_e09b2fd2-f39d-4327-92dd-5d40bd2418a1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a3140820-86f4-4014-802a-e0e945ac17a0" xlink:to="loc_us-gaap_Depreciation_e09b2fd2-f39d-4327-92dd-5d40bd2418a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_dee8f656-3c1e-4b58-b00e-77af2719b35c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a3140820-86f4-4014-802a-e0e945ac17a0" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_dee8f656-3c1e-4b58-b00e-77af2719b35c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_egrx_FairValueAdjustmentOnAcceleratedShareRepurchases_2a6b4fe6-ac9d-4adc-bbf0-6239d97fb395" xlink:href="egrx-20211231.xsd#egrx_FairValueAdjustmentOnAcceleratedShareRepurchases"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a3140820-86f4-4014-802a-e0e945ac17a0" xlink:to="loc_egrx_FairValueAdjustmentOnAcceleratedShareRepurchases_2a6b4fe6-ac9d-4adc-bbf0-6239d97fb395" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrealizedGainLossOnInvestments_7e0ab7b4-ede8-4190-8806-672792673350" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnrealizedGainLossOnInvestments"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a3140820-86f4-4014-802a-e0e945ac17a0" xlink:to="loc_us-gaap_UnrealizedGainLossOnInvestments_7e0ab7b4-ede8-4190-8806-672792673350" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_5c7a924f-866e-40cc-ae0c-0eaef56949df" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a3140820-86f4-4014-802a-e0e945ac17a0" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_5c7a924f-866e-40cc-ae0c-0eaef56949df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_bc02ca89-ff70-4803-8f82-f758bf486a4e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeGainLossOnDerivativeNet"/>
    <link:calculationArc order="15" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a3140820-86f4-4014-802a-e0e945ac17a0" xlink:to="loc_us-gaap_DerivativeGainLossOnDerivativeNet_bc02ca89-ff70-4803-8f82-f758bf486a4e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_123c89f1-2210-4d26-89fa-c0e4f3b5740f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a3140820-86f4-4014-802a-e0e945ac17a0" xlink:to="loc_us-gaap_NetIncomeLoss_123c89f1-2210-4d26-89fa-c0e4f3b5740f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_7d887555-6b8b-4f23-85f7-849a75efb515" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="17" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a3140820-86f4-4014-802a-e0e945ac17a0" xlink:to="loc_us-gaap_ShareBasedCompensation_7d887555-6b8b-4f23-85f7-849a75efb515" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleChangeInPresentValueExpenseReversal_4043e952-9176-442c-8713-732b94f6fc87" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleChangeInPresentValueExpenseReversal"/>
    <link:calculationArc order="18" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a3140820-86f4-4014-802a-e0e945ac17a0" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleChangeInPresentValueExpenseReversal_4043e952-9176-442c-8713-732b94f6fc87" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_f1f81137-b526-486a-aabb-3b001d7bd973" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c21e0370-447b-496b-a018-017f7cf09e73" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_f1f81137-b526-486a-aabb-3b001d7bd973" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c21e0370-447b-496b-a018-017f7cf09e73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_281a0bbf-65c8-4a5d-a736-f41a4f7e94bb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_f1f81137-b526-486a-aabb-3b001d7bd973" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_281a0bbf-65c8-4a5d-a736-f41a4f7e94bb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a0775370-c7cf-4ccb-8c09-971e0e481f60" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_f1f81137-b526-486a-aabb-3b001d7bd973" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a0775370-c7cf-4ccb-8c09-971e0e481f60" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eagleus.com/role/SummaryofSignificantAccountingPoliciesScheduleofFinancialAssetsandLiabilitiesMeasuredandRecognizedatFairValueDetails" xlink:type="simple" xlink:href="egrx-20211231.xsd#SummaryofSignificantAccountingPoliciesScheduleofFinancialAssetsandLiabilitiesMeasuredandRecognizedatFairValueDetails"/>
  <link:calculationLink xlink:role="http://www.eagleus.com/role/SummaryofSignificantAccountingPoliciesScheduleofFinancialAssetsandLiabilitiesMeasuredandRecognizedatFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_778b9911-2a67-4f9c-80f7-34491b1673f1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsFairValueDisclosure_64f0c963-66ce-44f2-884a-3cbe238bf4fc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssetsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_778b9911-2a67-4f9c-80f7-34491b1673f1" xlink:to="loc_us-gaap_OtherAssetsFairValueDisclosure_64f0c963-66ce-44f2-884a-3cbe238bf4fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeAsset_a2ccbfc3-36d3-4c1a-9fee-70a6729a864b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeAsset"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_778b9911-2a67-4f9c-80f7-34491b1673f1" xlink:to="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeAsset_a2ccbfc3-36d3-4c1a-9fee-70a6729a864b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesFairValueDisclosure_6a7b9dba-3077-4027-8592-20cb589613e9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesFairValueDisclosure"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_778b9911-2a67-4f9c-80f7-34491b1673f1" xlink:to="loc_us-gaap_ReceivablesFairValueDisclosure_6a7b9dba-3077-4027-8592-20cb589613e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_29af8131-b610-48d5-8982-b1889f8a8420" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_778b9911-2a67-4f9c-80f7-34491b1673f1" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_29af8131-b610-48d5-8982-b1889f8a8420" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eagleus.com/role/SummaryofSignificantAccountingPoliciesEarningsPerShareDetails" xlink:type="simple" xlink:href="egrx-20211231.xsd#SummaryofSignificantAccountingPoliciesEarningsPerShareDetails"/>
  <link:calculationLink xlink:role="http://www.eagleus.com/role/SummaryofSignificantAccountingPoliciesEarningsPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_8417cba4-aafb-47d1-a4e7-d937cac51ca5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_7b44e6ad-da2b-49b3-8722-3d8fcbc1c232" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_8417cba4-aafb-47d1-a4e7-d937cac51ca5" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_7b44e6ad-da2b-49b3-8722-3d8fcbc1c232" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_49f8ace7-5828-4c52-a881-0e4c37590c2e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_8417cba4-aafb-47d1-a4e7-d937cac51ca5" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_49f8ace7-5828-4c52-a881-0e4c37590c2e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eagleus.com/role/InventoriesDetails" xlink:type="simple" xlink:href="egrx-20211231.xsd#InventoriesDetails"/>
  <link:calculationLink xlink:role="http://www.eagleus.com/role/InventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_2cc76b48-255e-40d2-8dfd-8059e4bf7320" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterials_9741f64e-a52a-43c6-8f0a-0a162749b41d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryRawMaterials"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_2cc76b48-255e-40d2-8dfd-8059e4bf7320" xlink:to="loc_us-gaap_InventoryRawMaterials_9741f64e-a52a-43c6-8f0a-0a162749b41d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcess_eba993d3-e4a2-438a-a029-e8facca3c1e3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryWorkInProcess"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_2cc76b48-255e-40d2-8dfd-8059e4bf7320" xlink:to="loc_us-gaap_InventoryWorkInProcess_eba993d3-e4a2-438a-a029-e8facca3c1e3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoods_667b5e6f-0015-408e-8ee5-879acb52f814" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryFinishedGoods"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_2cc76b48-255e-40d2-8dfd-8059e4bf7320" xlink:to="loc_us-gaap_InventoryFinishedGoods_667b5e6f-0015-408e-8ee5-879acb52f814" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eagleus.com/role/PropertyandEquipmentnetDetails" xlink:type="simple" xlink:href="egrx-20211231.xsd#PropertyandEquipmentnetDetails"/>
  <link:calculationLink xlink:role="http://www.eagleus.com/role/PropertyandEquipmentnetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_381e663e-28c9-47d7-b83b-5facb1063f3a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_ea939b4d-6cd3-4f69-9c51-4a75a2c83440" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_381e663e-28c9-47d7-b83b-5facb1063f3a" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_ea939b4d-6cd3-4f69-9c51-4a75a2c83440" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_ca944559-c11b-4ac9-a3b3-cdf1501011fa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_381e663e-28c9-47d7-b83b-5facb1063f3a" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_ca944559-c11b-4ac9-a3b3-cdf1501011fa" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eagleus.com/role/BalanceSheetAccountsPrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="egrx-20211231.xsd#BalanceSheetAccountsPrepaidExpensesandOtherCurrentAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.eagleus.com/role/BalanceSheetAccountsPrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_5011c565-7ead-4f03-837f-b6febb6cc606" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_egrx_Advancestocommercialmanufactures_a89ea67b-63f1-407e-b9bb-b72636462b2b" xlink:href="egrx-20211231.xsd#egrx_Advancestocommercialmanufactures"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_5011c565-7ead-4f03-837f-b6febb6cc606" xlink:to="loc_egrx_Advancestocommercialmanufactures_a89ea67b-63f1-407e-b9bb-b72636462b2b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidTaxes_5172be59-f225-4f38-9aea-08be3f4ed22f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidTaxes"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_5011c565-7ead-4f03-837f-b6febb6cc606" xlink:to="loc_us-gaap_PrepaidTaxes_5172be59-f225-4f38-9aea-08be3f4ed22f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_6567d5f5-ac0a-4761-a928-a407cd9128ca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_5011c565-7ead-4f03-837f-b6febb6cc606" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_6567d5f5-ac0a-4761-a928-a407cd9128ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_egrx_PrepaidFDAUserFeeAndAdvancesToClinicalResearchOrganizations_a9c7c400-aefe-4c7e-8f22-a874a98b3b9b" xlink:href="egrx-20211231.xsd#egrx_PrepaidFDAUserFeeAndAdvancesToClinicalResearchOrganizations"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_5011c565-7ead-4f03-837f-b6febb6cc606" xlink:to="loc_egrx_PrepaidFDAUserFeeAndAdvancesToClinicalResearchOrganizations_a9c7c400-aefe-4c7e-8f22-a874a98b3b9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidInsurance_e7cfa64a-959a-4ff5-adcd-15757ec5054b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidInsurance"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_5011c565-7ead-4f03-837f-b6febb6cc606" xlink:to="loc_us-gaap_PrepaidInsurance_e7cfa64a-959a-4ff5-adcd-15757ec5054b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_1af08c89-3961-4e89-ae3f-1141b33cd5a8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_5011c565-7ead-4f03-837f-b6febb6cc606" xlink:to="loc_us-gaap_OtherAssetsCurrent_1af08c89-3961-4e89-ae3f-1141b33cd5a8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eagleus.com/role/BalanceSheetAccountsAccruedExpensesandOtherLiabilitiesDetails" xlink:type="simple" xlink:href="egrx-20211231.xsd#BalanceSheetAccountsAccruedExpensesandOtherLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.eagleus.com/role/BalanceSheetAccountsAccruedExpensesandOtherLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_04ee7ba2-75d0-4108-abc6-e439cc350bcc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedSalariesCurrent_05525e9c-50e1-45c7-b231-41aea9d3625f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedSalariesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_04ee7ba2-75d0-4108-abc6-e439cc350bcc" xlink:to="loc_us-gaap_AccruedSalariesCurrent_05525e9c-50e1-45c7-b231-41aea9d3625f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_egrx_AccruedProductSalesReservesCurrent_2c015ee5-ff7c-47dd-a9c6-cbfa4382401e" xlink:href="egrx-20211231.xsd#egrx_AccruedProductSalesReservesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_04ee7ba2-75d0-4108-abc6-e439cc350bcc" xlink:to="loc_egrx_AccruedProductSalesReservesCurrent_2c015ee5-ff7c-47dd-a9c6-cbfa4382401e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedRoyaltiesCurrent_5305bd75-dbf7-4f71-a7b3-3a203c60aeb7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedRoyaltiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_04ee7ba2-75d0-4108-abc6-e439cc350bcc" xlink:to="loc_us-gaap_AccruedRoyaltiesCurrent_5305bd75-dbf7-4f71-a7b3-3a203c60aeb7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_c1d26a68-060e-4d05-b395-9a2eaf508f98" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_04ee7ba2-75d0-4108-abc6-e439cc350bcc" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_c1d26a68-060e-4d05-b395-9a2eaf508f98" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_10d592dd-2587-45ef-b2e3-bdae6f0d78a0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_04ee7ba2-75d0-4108-abc6-e439cc350bcc" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_10d592dd-2587-45ef-b2e3-bdae6f0d78a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_egrx_AccruedResearchandDevelopmentCurrent_0495f90e-7554-437c-8368-e9c6492677f9" xlink:href="egrx-20211231.xsd#egrx_AccruedResearchandDevelopmentCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_04ee7ba2-75d0-4108-abc6-e439cc350bcc" xlink:to="loc_egrx_AccruedResearchandDevelopmentCurrent_0495f90e-7554-437c-8368-e9c6492677f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_d7e143ac-f451-4479-846a-d8d10dd744fe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_04ee7ba2-75d0-4108-abc6-e439cc350bcc" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_d7e143ac-f451-4479-846a-d8d10dd744fe" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eagleus.com/role/BalanceSheetAccountsLeaseRelatedDisclosuresDetails" xlink:type="simple" xlink:href="egrx-20211231.xsd#BalanceSheetAccountsLeaseRelatedDisclosuresDetails"/>
  <link:calculationLink xlink:role="http://www.eagleus.com/role/BalanceSheetAccountsLeaseRelatedDisclosuresDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_0fcecfba-82eb-430a-8c65-0b389471c792" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_d42606cb-4b16-43a5-9b32-4e54cf5db35a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_0fcecfba-82eb-430a-8c65-0b389471c792" xlink:to="loc_us-gaap_OperatingLeaseCost_d42606cb-4b16-43a5-9b32-4e54cf5db35a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_d0565faf-fe30-4aef-8a5a-8c62eb5f41d8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_050be607-3bb5-4a0a-97f7-041a38bf6bd7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_d0565faf-fe30-4aef-8a5a-8c62eb5f41d8" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_050be607-3bb5-4a0a-97f7-041a38bf6bd7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_98e20e5e-ae7c-4347-a3a5-0dc42a692799" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_d0565faf-fe30-4aef-8a5a-8c62eb5f41d8" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_98e20e5e-ae7c-4347-a3a5-0dc42a692799" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eagleus.com/role/IncomeTaxesScheduleofComponentsofIncomeTaxExpenseBenefitDetails" xlink:type="simple" xlink:href="egrx-20211231.xsd#IncomeTaxesScheduleofComponentsofIncomeTaxExpenseBenefitDetails"/>
  <link:calculationLink xlink:role="http://www.eagleus.com/role/IncomeTaxesScheduleofComponentsofIncomeTaxExpenseBenefitDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_86149152-efe0-4fe0-9ba1-850a9806680c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentFederalTaxExpenseBenefit_08953784-5ff0-43e0-9111-1612c6f62bbf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CurrentFederalTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_86149152-efe0-4fe0-9ba1-850a9806680c" xlink:to="loc_us-gaap_CurrentFederalTaxExpenseBenefit_08953784-5ff0-43e0-9111-1612c6f62bbf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_c09a4a50-5c0e-4ac9-8c8b-b8e144195e01" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CurrentStateAndLocalTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_86149152-efe0-4fe0-9ba1-850a9806680c" xlink:to="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_c09a4a50-5c0e-4ac9-8c8b-b8e144195e01" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_0c5cc9f5-1281-4cf0-be38-d82d43c2155d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_7827108a-63ce-4865-ad87-2ee9851008d9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_0c5cc9f5-1281-4cf0-be38-d82d43c2155d" xlink:to="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_7827108a-63ce-4865-ad87-2ee9851008d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_adfbacfb-e396-4cc5-a8d0-e1d966494ab2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_0c5cc9f5-1281-4cf0-be38-d82d43c2155d" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_adfbacfb-e396-4cc5-a8d0-e1d966494ab2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_361014ab-7424-4048-8104-2e68c0740dc2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_518dcb68-faf6-4a2e-be46-914d92bef263" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_361014ab-7424-4048-8104-2e68c0740dc2" xlink:to="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_518dcb68-faf6-4a2e-be46-914d92bef263" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_b2b68488-f348-4a66-837c-7b0a99271931" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_361014ab-7424-4048-8104-2e68c0740dc2" xlink:to="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_b2b68488-f348-4a66-837c-7b0a99271931" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eagleus.com/role/IncomeTaxesScheduleofEffectiveIncomeTaxRateReconciliationDetails" xlink:type="simple" xlink:href="egrx-20211231.xsd#IncomeTaxesScheduleofEffectiveIncomeTaxRateReconciliationDetails"/>
  <link:calculationLink xlink:role="http://www.eagleus.com/role/IncomeTaxesScheduleofEffectiveIncomeTaxRateReconciliationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_998835be-2a2a-4e06-8988-01065d087da7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_e50e7cb7-e1c9-4d94-b908-fff6caf78fab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_998835be-2a2a-4e06-8988-01065d087da7" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_e50e7cb7-e1c9-4d94-b908-fff6caf78fab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_f4bc4f38-b20d-4c95-961f-a92bd0aeb074" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_998835be-2a2a-4e06-8988-01065d087da7" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_f4bc4f38-b20d-4c95-961f-a92bd0aeb074" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_e2711afd-8fea-4be9-a30f-fa539a2df164" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_998835be-2a2a-4e06-8988-01065d087da7" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_e2711afd-8fea-4be9-a30f-fa539a2df164" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_egrx_EffectiveIncomeTaxRateReconciliationLimitationOnExecutiveCompensationPercent_b840fabc-a66f-4b3a-9f48-520930044247" xlink:href="egrx-20211231.xsd#egrx_EffectiveIncomeTaxRateReconciliationLimitationOnExecutiveCompensationPercent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_998835be-2a2a-4e06-8988-01065d087da7" xlink:to="loc_egrx_EffectiveIncomeTaxRateReconciliationLimitationOnExecutiveCompensationPercent_b840fabc-a66f-4b3a-9f48-520930044247" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_egrx_EffectiveIncomeTaxRateReconciliationSharebasedCompensationExcessTaxBenefit_12ae451a-0d04-4b02-870e-d2b8357ac85f" xlink:href="egrx-20211231.xsd#egrx_EffectiveIncomeTaxRateReconciliationSharebasedCompensationExcessTaxBenefit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_998835be-2a2a-4e06-8988-01065d087da7" xlink:to="loc_egrx_EffectiveIncomeTaxRateReconciliationSharebasedCompensationExcessTaxBenefit_12ae451a-0d04-4b02-870e-d2b8357ac85f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits_b74b31c8-a4e0-4a72-91c7-e92116793462" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_998835be-2a2a-4e06-8988-01065d087da7" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits_b74b31c8-a4e0-4a72-91c7-e92116793462" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_6b93e7fb-e270-4065-80d9-5ff640eb3e58" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_998835be-2a2a-4e06-8988-01065d087da7" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_6b93e7fb-e270-4065-80d9-5ff640eb3e58" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_36296e97-eb2c-411d-a924-cf093d2f7482" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_998835be-2a2a-4e06-8988-01065d087da7" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_36296e97-eb2c-411d-a924-cf093d2f7482" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eagleus.com/role/IncomeTaxesScheduleofEffectiveIncomeTaxRateReconciliationDetails_1" xlink:type="simple" xlink:href="egrx-20211231.xsd#IncomeTaxesScheduleofEffectiveIncomeTaxRateReconciliationDetails_1"/>
  <link:calculationLink xlink:role="http://www.eagleus.com/role/IncomeTaxesScheduleofEffectiveIncomeTaxRateReconciliationDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_6b2b834b-db84-41e8-b806-92f97714773c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_9abc743a-4171-4f87-856e-b6527b2539a1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_6b2b834b-db84-41e8-b806-92f97714773c" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_9abc743a-4171-4f87-856e-b6527b2539a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_b10f6ca6-e85d-405c-9452-78b27d0942b6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_6b2b834b-db84-41e8-b806-92f97714773c" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_b10f6ca6-e85d-405c-9452-78b27d0942b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_egrx_EffectiveIncomeTaxRateReconciliationSharebasedCompensationExcessTaxBenefit_e90d4ef3-162c-4212-bb67-d8934ad3d3d2" xlink:href="egrx-20211231.xsd#egrx_EffectiveIncomeTaxRateReconciliationSharebasedCompensationExcessTaxBenefit"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_6b2b834b-db84-41e8-b806-92f97714773c" xlink:to="loc_egrx_EffectiveIncomeTaxRateReconciliationSharebasedCompensationExcessTaxBenefit_e90d4ef3-162c-4212-bb67-d8934ad3d3d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits_9291af99-6dd3-4ee7-9677-3c16a6603133" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_6b2b834b-db84-41e8-b806-92f97714773c" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits_9291af99-6dd3-4ee7-9677-3c16a6603133" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_egrx_EffectiveIncomeTaxRateReconciliationLimitationOnExecutiveCompensationPercent_7c185ca3-fa17-440f-bbf6-4ceb3fceff05" xlink:href="egrx-20211231.xsd#egrx_EffectiveIncomeTaxRateReconciliationLimitationOnExecutiveCompensationPercent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_6b2b834b-db84-41e8-b806-92f97714773c" xlink:to="loc_egrx_EffectiveIncomeTaxRateReconciliationLimitationOnExecutiveCompensationPercent_7c185ca3-fa17-440f-bbf6-4ceb3fceff05" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_904aa983-7db1-469c-96fe-4169f521b69c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_6b2b834b-db84-41e8-b806-92f97714773c" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_904aa983-7db1-469c-96fe-4169f521b69c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_1cfc5144-39a7-4142-a9b9-e24b9c9d32d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_6b2b834b-db84-41e8-b806-92f97714773c" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_1cfc5144-39a7-4142-a9b9-e24b9c9d32d3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eagleus.com/role/IncomeTaxesScheduleofDeferredTaxAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="egrx-20211231.xsd#IncomeTaxesScheduleofDeferredTaxAssetsandLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.eagleus.com/role/IncomeTaxesScheduleofDeferredTaxAssetsandLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_116b2bcd-7b58-476a-8543-324673a97871" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_4cadaa86-3a92-4c34-8b9c-b5700b8734f2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_116b2bcd-7b58-476a-8543-324673a97871" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_4cadaa86-3a92-4c34-8b9c-b5700b8734f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsInvestments_56bd0c06-f3e4-414c-a107-bb43d66cb8f1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_116b2bcd-7b58-476a-8543-324673a97871" xlink:to="loc_us-gaap_DeferredTaxAssetsInvestments_56bd0c06-f3e4-414c-a107-bb43d66cb8f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsInventory_3ab02f98-79c9-4e8a-a5f6-f35d5e3983a5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsInventory"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_116b2bcd-7b58-476a-8543-324673a97871" xlink:to="loc_us-gaap_DeferredTaxAssetsInventory_3ab02f98-79c9-4e8a-a5f6-f35d5e3983a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_6d7d19da-efcf-4a75-9f8d-79a9300b2905" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsOther"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_116b2bcd-7b58-476a-8543-324673a97871" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_6d7d19da-efcf-4a75-9f8d-79a9300b2905" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_egrx_DeferredTaxAssetsOperatingLeaseRightOfUseLiability_bc38392f-e12a-4ade-a77b-78939ca6998a" xlink:href="egrx-20211231.xsd#egrx_DeferredTaxAssetsOperatingLeaseRightOfUseLiability"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_116b2bcd-7b58-476a-8543-324673a97871" xlink:to="loc_egrx_DeferredTaxAssetsOperatingLeaseRightOfUseLiability_bc38392f-e12a-4ade-a77b-78939ca6998a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch_097ffb82-df84-461d-9201-ef3ff1ecded9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_116b2bcd-7b58-476a-8543-324673a97871" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch_097ffb82-df84-461d-9201-ef3ff1ecded9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation_f06b8d29-820d-415f-a6cb-3427efe351a8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_116b2bcd-7b58-476a-8543-324673a97871" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation_f06b8d29-820d-415f-a6cb-3427efe351a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_41719377-6745-484f-a024-e71d9819062b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_116b2bcd-7b58-476a-8543-324673a97871" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_41719377-6745-484f-a024-e71d9819062b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets_d832df2c-340b-4215-a988-4a3e96ff1529" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_116b2bcd-7b58-476a-8543-324673a97871" xlink:to="loc_us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets_d832df2c-340b-4215-a988-4a3e96ff1529" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_158a7489-651c-4767-b734-8ae9e5d6d415" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_99e180af-a489-45c5-87b3-b41d2fe7a664" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_158a7489-651c-4767-b734-8ae9e5d6d415" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_99e180af-a489-45c5-87b3-b41d2fe7a664" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_06bdbb0d-3357-44b7-b1ea-3d842064f572" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_158a7489-651c-4767-b734-8ae9e5d6d415" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_06bdbb0d-3357-44b7-b1ea-3d842064f572" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_43a9d931-597a-4eea-ba2b-47d829c2b978" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_158a7489-651c-4767-b734-8ae9e5d6d415" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_43a9d931-597a-4eea-ba2b-47d829c2b978" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_a2bf517d-9bee-497f-8827-94c276c6b990" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets_1bdcf580-fd9f-47d4-85b9-bf313e85c8e4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_a2bf517d-9bee-497f-8827-94c276c6b990" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets_1bdcf580-fd9f-47d4-85b9-bf313e85c8e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesPrepaidExpenses_4cf4d8f3-7f4c-4ec1-a925-3720f0ec0f98" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxLiabilitiesPrepaidExpenses"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_a2bf517d-9bee-497f-8827-94c276c6b990" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesPrepaidExpenses_4cf4d8f3-7f4c-4ec1-a925-3720f0ec0f98" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_egrx_DeferredTaxLiabilitiesFixedAssets_e1a8882b-b28f-4e3e-8c75-a0b75567eb97" xlink:href="egrx-20211231.xsd#egrx_DeferredTaxLiabilitiesFixedAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_a2bf517d-9bee-497f-8827-94c276c6b990" xlink:to="loc_egrx_DeferredTaxLiabilitiesFixedAssets_e1a8882b-b28f-4e3e-8c75-a0b75567eb97" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesLeasingArrangements_2c5821e9-cb6e-4c60-85be-732bc2e5af6f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxLiabilitiesLeasingArrangements"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_a2bf517d-9bee-497f-8827-94c276c6b990" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesLeasingArrangements_2c5821e9-cb6e-4c60-85be-732bc2e5af6f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eagleus.com/role/CommitmentsDetails" xlink:type="simple" xlink:href="egrx-20211231.xsd#CommitmentsDetails"/>
  <link:calculationLink xlink:role="http://www.eagleus.com/role/CommitmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_abf440b5-fbe1-47e9-957f-f1f65e318ea4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_d8878fe3-9846-4828-8433-fe5fac279306" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_abf440b5-fbe1-47e9-957f-f1f65e318ea4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_d8878fe3-9846-4828-8433-fe5fac279306" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_bb0dcb02-b09f-4c53-8a2d-309e24131df8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_abf440b5-fbe1-47e9-957f-f1f65e318ea4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_bb0dcb02-b09f-4c53-8a2d-309e24131df8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_074189bf-e2e9-44dd-ac20-75cb4bdd83b5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_abf440b5-fbe1-47e9-957f-f1f65e318ea4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_074189bf-e2e9-44dd-ac20-75cb4bdd83b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_6eb6109c-21c4-4493-abf9-b987d6e07a7d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_abf440b5-fbe1-47e9-957f-f1f65e318ea4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_6eb6109c-21c4-4493-abf9-b987d6e07a7d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractualObligation_20a14d08-6416-4d40-ad2f-fbb02f5fdebf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractualObligation"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractualObligationDueInSecondYear_1b06d705-f95f-4798-9605-56b4defe420a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractualObligationDueInSecondYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligation_20a14d08-6416-4d40-ad2f-fbb02f5fdebf" xlink:to="loc_us-gaap_ContractualObligationDueInSecondYear_1b06d705-f95f-4798-9605-56b4defe420a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractualObligationDueInFourthYear_ce39d966-50b9-4e0e-9a3b-ec8005ac5999" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractualObligationDueInFourthYear"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligation_20a14d08-6416-4d40-ad2f-fbb02f5fdebf" xlink:to="loc_us-gaap_ContractualObligationDueInFourthYear_ce39d966-50b9-4e0e-9a3b-ec8005ac5999" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractualObligationDueInNextTwelveMonths_63e8eaf7-f849-4592-b677-ab6ce014cad7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractualObligationDueInNextTwelveMonths"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligation_20a14d08-6416-4d40-ad2f-fbb02f5fdebf" xlink:to="loc_us-gaap_ContractualObligationDueInNextTwelveMonths_63e8eaf7-f849-4592-b677-ab6ce014cad7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractualObligationDueInThirdYear_72b89604-3e26-49a0-85bd-37753c583c03" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractualObligationDueInThirdYear"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligation_20a14d08-6416-4d40-ad2f-fbb02f5fdebf" xlink:to="loc_us-gaap_ContractualObligationDueInThirdYear_72b89604-3e26-49a0-85bd-37753c583c03" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_c3b74644-11e4-4d36-93a0-f9b7f1e4ff4f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_5dd6d538-b313-4436-9f6f-17742cb5c441" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_c3b74644-11e4-4d36-93a0-f9b7f1e4ff4f" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_5dd6d538-b313-4436-9f6f-17742cb5c441" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_9b1192b4-971b-43a2-84cf-4adea9b215cc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_c3b74644-11e4-4d36-93a0-f9b7f1e4ff4f" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_9b1192b4-971b-43a2-84cf-4adea9b215cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_65b2b399-b37c-406e-acd5-5659916de5ae" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_c3b74644-11e4-4d36-93a0-f9b7f1e4ff4f" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_65b2b399-b37c-406e-acd5-5659916de5ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_a0cff791-d169-4450-9a9d-000d94cd0517" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_c3b74644-11e4-4d36-93a0-f9b7f1e4ff4f" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_a0cff791-d169-4450-9a9d-000d94cd0517" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractualObligationDueInFourthYear_417c7811-67e4-4946-8992-927caf8f6d97" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractualObligationDueInFourthYear"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_536d6f70-15ac-4ab6-99ae-9f6df9a39259" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligationDueInFourthYear_417c7811-67e4-4946-8992-927caf8f6d97" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_536d6f70-15ac-4ab6-99ae-9f6df9a39259" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_e3878dbb-8d8a-47bf-8857-93e38f8949f3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligationDueInFourthYear_417c7811-67e4-4946-8992-927caf8f6d97" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_e3878dbb-8d8a-47bf-8857-93e38f8949f3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligationDueInFourthYear_1112c9fa-be7b-4e42-aa5c-6bcaa5a824bd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PurchaseObligationDueInFourthYear"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligationDueInFourthYear_417c7811-67e4-4946-8992-927caf8f6d97" xlink:to="loc_us-gaap_PurchaseObligationDueInFourthYear_1112c9fa-be7b-4e42-aa5c-6bcaa5a824bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligation_5e5c90e6-9397-498f-baec-194057358943" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PurchaseObligation"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligationDueInFourthYear_8b90c128-1cf6-4474-b604-181c03c3218f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PurchaseObligationDueInFourthYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PurchaseObligation_5e5c90e6-9397-498f-baec-194057358943" xlink:to="loc_us-gaap_PurchaseObligationDueInFourthYear_8b90c128-1cf6-4474-b604-181c03c3218f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligationDueInThirdYear_4273f3aa-e49d-47ec-8582-4847be7deeba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PurchaseObligationDueInThirdYear"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PurchaseObligation_5e5c90e6-9397-498f-baec-194057358943" xlink:to="loc_us-gaap_PurchaseObligationDueInThirdYear_4273f3aa-e49d-47ec-8582-4847be7deeba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligationDueInNextTwelveMonths_dfe6202e-f4dd-4862-818f-c6ea5e890982" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PurchaseObligationDueInNextTwelveMonths"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PurchaseObligation_5e5c90e6-9397-498f-baec-194057358943" xlink:to="loc_us-gaap_PurchaseObligationDueInNextTwelveMonths_dfe6202e-f4dd-4862-818f-c6ea5e890982" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligationDueInSecondYear_003051a6-fcab-479b-a479-16b4547a9670" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PurchaseObligationDueInSecondYear"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PurchaseObligation_5e5c90e6-9397-498f-baec-194057358943" xlink:to="loc_us-gaap_PurchaseObligationDueInSecondYear_003051a6-fcab-479b-a479-16b4547a9670" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractualObligationDueInThirdYear_c1717780-e335-40fb-a528-651ad27aa445" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractualObligationDueInThirdYear"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_f45d0592-8201-4b6f-a970-62166548a063" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligationDueInThirdYear_c1717780-e335-40fb-a528-651ad27aa445" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_f45d0592-8201-4b6f-a970-62166548a063" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_df13db84-14d6-424e-b293-9f2c9c5b8e68" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligationDueInThirdYear_c1717780-e335-40fb-a528-651ad27aa445" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_df13db84-14d6-424e-b293-9f2c9c5b8e68" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligationDueInThirdYear_dacf6726-2972-4801-96aa-3ec396759f7b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PurchaseObligationDueInThirdYear"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligationDueInThirdYear_c1717780-e335-40fb-a528-651ad27aa445" xlink:to="loc_us-gaap_PurchaseObligationDueInThirdYear_dacf6726-2972-4801-96aa-3ec396759f7b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractualObligationDueInNextTwelveMonths_ad969246-1673-4208-9638-87b61c86c105" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractualObligationDueInNextTwelveMonths"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_3fa3836f-7a8d-42dc-b7d1-d646cf4af8de" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligationDueInNextTwelveMonths_ad969246-1673-4208-9638-87b61c86c105" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_3fa3836f-7a8d-42dc-b7d1-d646cf4af8de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_9897c721-6d9b-4790-a4df-80122e1dedd2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligationDueInNextTwelveMonths_ad969246-1673-4208-9638-87b61c86c105" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_9897c721-6d9b-4790-a4df-80122e1dedd2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligationDueInNextTwelveMonths_530ee17d-6686-4ff8-8e04-4567ddf57300" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PurchaseObligationDueInNextTwelveMonths"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligationDueInNextTwelveMonths_ad969246-1673-4208-9638-87b61c86c105" xlink:to="loc_us-gaap_PurchaseObligationDueInNextTwelveMonths_530ee17d-6686-4ff8-8e04-4567ddf57300" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractualObligationDueInSecondYear_0532c787-9595-489b-99c2-1564c57d88e6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractualObligationDueInSecondYear"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_2bbe85b3-c976-4d6e-8413-3d0d4da48566" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligationDueInSecondYear_0532c787-9595-489b-99c2-1564c57d88e6" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_2bbe85b3-c976-4d6e-8413-3d0d4da48566" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_6dcc408f-76ed-45c9-b9c7-3cb5978091cc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligationDueInSecondYear_0532c787-9595-489b-99c2-1564c57d88e6" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_6dcc408f-76ed-45c9-b9c7-3cb5978091cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligationDueInSecondYear_45ba3e93-62fe-47bb-a03d-640f00da3fae" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PurchaseObligationDueInSecondYear"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligationDueInSecondYear_0532c787-9595-489b-99c2-1564c57d88e6" xlink:to="loc_us-gaap_PurchaseObligationDueInSecondYear_45ba3e93-62fe-47bb-a03d-640f00da3fae" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eagleus.com/role/CommitmentsDetails_1" xlink:type="simple" xlink:href="egrx-20211231.xsd#CommitmentsDetails_1"/>
  <link:calculationLink xlink:role="http://www.eagleus.com/role/CommitmentsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractualObligation_ba70d5fe-a7a1-4ed3-8cd1-a615b06b51a4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractualObligation"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_01dcb592-bfab-4750-83d2-59f4ee17a68e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligation_ba70d5fe-a7a1-4ed3-8cd1-a615b06b51a4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_01dcb592-bfab-4750-83d2-59f4ee17a68e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_41ae2fe4-4d5e-4e2b-944a-5389fdfb71a0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligation_ba70d5fe-a7a1-4ed3-8cd1-a615b06b51a4" xlink:to="loc_us-gaap_LongTermDebt_41ae2fe4-4d5e-4e2b-944a-5389fdfb71a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligation_15867db1-3883-46d8-972a-102141ec5618" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PurchaseObligation"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligation_ba70d5fe-a7a1-4ed3-8cd1-a615b06b51a4" xlink:to="loc_us-gaap_PurchaseObligation_15867db1-3883-46d8-972a-102141ec5618" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_6cbe7fb8-321b-4b15-88e1-4fb5a17bb476" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_f8eb4f94-9d35-4e7f-9b08-0bb979d43042" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_6cbe7fb8-321b-4b15-88e1-4fb5a17bb476" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_f8eb4f94-9d35-4e7f-9b08-0bb979d43042" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_93c10841-c1fd-488c-ba29-8968a37d80d7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_6cbe7fb8-321b-4b15-88e1-4fb5a17bb476" xlink:to="loc_us-gaap_OperatingLeaseLiability_93c10841-c1fd-488c-ba29-8968a37d80d7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eagleus.com/role/IntangibleAssetsNetScheduleofIntangibleAssetsDetails" xlink:type="simple" xlink:href="egrx-20211231.xsd#IntangibleAssetsNetScheduleofIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.eagleus.com/role/IntangibleAssetsNetScheduleofIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_e5b6b8aa-014d-47e7-b06f-e241f66c20b8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_fa2252d6-c821-4c46-9060-abc307965137" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_e5b6b8aa-014d-47e7-b06f-e241f66c20b8" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_fa2252d6-c821-4c46-9060-abc307965137" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_94c34817-d1f8-480b-9b0b-2765bddbfdcc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_e5b6b8aa-014d-47e7-b06f-e241f66c20b8" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_94c34817-d1f8-480b-9b0b-2765bddbfdcc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_egrx_FiniteLivedIntangibleAssetsImpairment_cc33a6af-d1fc-434b-b08f-f8fa98a4297e" xlink:href="egrx-20211231.xsd#egrx_FiniteLivedIntangibleAssetsImpairment"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_e5b6b8aa-014d-47e7-b06f-e241f66c20b8" xlink:to="loc_egrx_FiniteLivedIntangibleAssetsImpairment_cc33a6af-d1fc-434b-b08f-f8fa98a4297e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eagleus.com/role/IntangibleAssetsNetScheduleofFutureAmortizationExpenseDetails" xlink:type="simple" xlink:href="egrx-20211231.xsd#IntangibleAssetsNetScheduleofFutureAmortizationExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.eagleus.com/role/IntangibleAssetsNetScheduleofFutureAmortizationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_29f7065b-8b62-4f5f-a5ce-b57e536f4c00" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_4f1ca6fe-7839-4b70-bdfa-89ce5ff067c7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_29f7065b-8b62-4f5f-a5ce-b57e536f4c00" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_4f1ca6fe-7839-4b70-bdfa-89ce5ff067c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_egrx_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour_eceae82b-691b-48a3-81fd-9397bf3d0276" xlink:href="egrx-20211231.xsd#egrx_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_29f7065b-8b62-4f5f-a5ce-b57e536f4c00" xlink:to="loc_egrx_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour_eceae82b-691b-48a3-81fd-9397bf3d0276" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_0ece853a-f649-40d0-a468-4ca5bda705de" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_29f7065b-8b62-4f5f-a5ce-b57e536f4c00" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_0ece853a-f649-40d0-a468-4ca5bda705de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_83441eaa-0e83-4d39-a901-abf7ff2d3ce0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_29f7065b-8b62-4f5f-a5ce-b57e536f4c00" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_83441eaa-0e83-4d39-a901-abf7ff2d3ce0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_3fca4c93-af75-4c7b-b6e7-6722355f4fcf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_29f7065b-8b62-4f5f-a5ce-b57e536f4c00" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_3fca4c93-af75-4c7b-b6e7-6722355f4fcf" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eagleus.com/role/ConvertiblePromissoryNoteDetails" xlink:type="simple" xlink:href="egrx-20211231.xsd#ConvertiblePromissoryNoteDetails"/>
  <link:calculationLink xlink:role="http://www.eagleus.com/role/ConvertiblePromissoryNoteDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_eba30088-dabf-4b94-9012-3c2c8f24508a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeAsset_659c9df8-ae6e-4da2-906d-35eb557e411d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_eba30088-dabf-4b94-9012-3c2c8f24508a" xlink:to="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeAsset_659c9df8-ae6e-4da2-906d-35eb557e411d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_1e8dd140-4f0e-47ea-bf84-8eb9a9ca1ebd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_eba30088-dabf-4b94-9012-3c2c8f24508a" xlink:to="loc_us-gaap_ReceivablesNetCurrent_1e8dd140-4f0e-47ea-bf84-8eb9a9ca1ebd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAccruedInterestAfterAllowanceForCreditLoss_37807287-2728-4d5f-9aeb-c01d2edc554b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleAccruedInterestAfterAllowanceForCreditLoss"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_eba30088-dabf-4b94-9012-3c2c8f24508a" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAccruedInterestAfterAllowanceForCreditLoss_37807287-2728-4d5f-9aeb-c01d2edc554b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_5ce7e187-a418-478b-8247-e3572ae02293" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivableWithImputedInterestDiscount_f02602fe-fc2f-4979-bdaf-b5106857ffa9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivableWithImputedInterestDiscount"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ReceivablesNetCurrent_5ce7e187-a418-478b-8247-e3572ae02293" xlink:to="loc_us-gaap_ReceivableWithImputedInterestDiscount_f02602fe-fc2f-4979-bdaf-b5106857ffa9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableFairValueDisclosure_d5e7749a-8a75-46c0-be8f-57ef2b536b76" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NotesReceivableFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ReceivablesNetCurrent_5ce7e187-a418-478b-8247-e3572ae02293" xlink:to="loc_us-gaap_NotesReceivableFairValueDisclosure_d5e7749a-8a75-46c0-be8f-57ef2b536b76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLoss_e3b1eeb0-124f-47a9-8ca8-f532fcc81a60" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLoss"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ReceivablesNetCurrent_5ce7e187-a418-478b-8247-e3572ae02293" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLoss_e3b1eeb0-124f-47a9-8ca8-f532fcc81a60" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
